A randomized clinical trial comparing family-focused treatment and individual supportive therapy for depression in childhood and early adolescence

OBJECTIVE: Despite the morbidity and negative outcomes associated with early-onset depression, few studies have examined the efficacy of psychosocial treatment for depressive disorders during childhood. Integrating family in treatment could have particularly salutary effects during this developmental period. This trial compared immediate posttreatment effects of family-focused treatment for childhood depression (FFT-CD) with those of individual supportive psychotherapy (IP) for children 7 to 14 years old with depressive disorders. METHOD: Children were randomized to 15 sessions of FFT-CD (n = 67) or IP (n = 67) over 4 months. The primary treatment outcome was adequate clinical depression response, defined as at least a 50% decrease in score on the Children's Depression Rating Scale-Revised (CDRS-R). Additional outcomes included patient-centered outcomes (parent- and child-reported treatment satisfaction), remission (defined as CDRS-R score ≤28), change in continuous CDRS-R score, and change in child and parent reports of depressive and non-depressive symptoms and social adjustment. RESULTS: Significant improvement was evident across groups for depressive and non-depressive symptoms, global response, and functioning and social adjustment. Compared with children randomized to IP, children randomized to FFT-CD showed higher rates of adequate clinical depression response (77.7% versus 59.9%; number needed to treat = 5.72; odds ratio 2.29; 95% CI 1.001-5.247; t = 1.97, p = .0498). Across treatments, families reported high satisfaction; compared with IP families, FFT-CD families reported greater knowledge and skills for managing depression. There were no significant differences between treatment arms on secondary outcomes. CONCLUSION: Results support the value of psychosocial intervention, emphasize the important role that families play, and highlight the potential for FFT-CD for supporting recovery in children with depression. Clinical trial registration information-Systems of Support Study for Childhood Depression; http://clinicaltrials.gov; NCT01159041.R01 MH082856 - NIMH NIH HHS; R01 MH082861 - NIMH NIH HH

Semileptonic Decays of Heavy Mesons with the Fat Clover Action

We are studying a variety of semileptonic decays of heavy-light mesons in an effort to improve the determination of the heavy-quark Standard-Model CKM matrix elements. Our fermion action is a novel, improved ``fat'' clover action that promises to reduce problems with exceptional configurations. Dynamical sea quarks are included in a mixed approach, i.e. we use staggered sea quarks and fat-clover valence quarks. Here we report preliminary results.Comment: LATTICE99(heavyqk) - 3p, 4 Postscript fig

Chiral logs with staggered fermions

We compute chiral logarithms in the presence of "taste" symmetry breaking of staggered fermions. The lagrangian of Lee and Sharpe is generalized and then used to calculate the logs in $\pi$ and $K$ masses. We correct an error in Ref. [1] [C. Bernard, hep-lat/0111051]; the issue turns out to have implications for the comparison with simulations, even at tree level. MILC data with three light dynamical flavors can be well fit by our formulas. However, two new chiral parameters, which describe order $a^2$ hairpin diagrams for taste-nonsinglet mesons, enter in the fits. To obtain precise results for the physical coefficients at order $p^4$, these new parameters will need to be bounded, at least roughly.Comment: talk presented by C. Bernard at Lattice2002(spectrum); 3 pages, 2 figure

The equation of state with nonzero chemical potential for 2+1 flavors

We present results for the QCD equation of state with nonzero chemical potential using the Taylor expansion method with terms up to sixth order in the expansion. Our calculations are performed on asqtad 2+1 quark flavor lattices at $N_t=4$.Comment: Talk given at the XXV International Symposium on Lattice Field Theory, July 30-4 August 2007, Regensburg, German

The locality of the fourth root of staggered fermion determinant in the interacting case

The fourth root approximation in LQCD simulations with dynamical staggered fermions requires justification. We test its validity numerically in the interacting theory in a renormalization group framework.Comment: 6 pages, Talk presented at Lattice 2005 (Machines and Algorithms

Heavy-Light Decay Constants: Conclusions from the Wilson Action

We report on the results of a MILC collaboration calculation of $f_B$, $f_{B_s}$, $f_D$, $f_{D_s}$ and their ratios. We discuss the most important errors in more detail than we have elsewhere.Comment: LATTICE98(heavyqk) 3 latex pages and 3 postscript figures. The perturbative correction calculated by Kuramashi has been adjusted to take into account the fact that we match to the continuum at the kinetic mass of the heavy meson, not the pole mass. This produces a 2 to 4 MeV change in final results for decay constants, and has negligible effect on decay constant ratio

Baryon masses with improved staggered quarks

The MILC collaboration's simulations with improved staggered quarks are being extended with runs at a lattice spacing of 0.06 fm with quark masses down to one tenth the strange quark mass. We give a brief introduction to these new simulations and the determination of the lattice spacing. Then we combine these new runs with older results to study the masses of the nucleon and the Omega minus in the continuum and chiral limits.Comment: 7 pages, proceedings from Lattice 2007 conferenc